The following schools are hosting Apply Missouri events for the 2021-22 school year:
- Affton High School
- Bayless High School
- Belton High School
- Blue Eye High School
- Bolivar High School
- Boonville High School
- Cabool High School
- Cainsville High Scool
- Campbell High School
- Capital City High School
- Cape Central High School
- Carnahan High School of the Future
- Carrollton High School
- Central High School
- Central Visual & Performing Arts
- Centralia High School
- Clyde C. Miller Career Academy
- Collegiate School of Medicine and Bioscience
- Crocker High School
- Drexel R-IV
- Everton High School
- Fair Play High School
- Festus Senior High School
- Fort Osage High School – Missouri College Advising Corps
- Gateway STEM High School
- Halfway High School
- Hazelwood Opportunity Center
- Hazelwood West High School
- Hillcrest High School
- Holt High School
- Jefferson High School
- Kickapoo High School
- KIPP High School
- Lebanon High School
- Liberty High School
- Louisiana High School
- Marion C. Early High School
- Mark Twain High School
- McCluer High School
- McCluer North High School
- Miriam Academy
- Monett High School
- Monroe City R-1 High School
- Northeast High School
- Notre Dame High School
- Odessa High School
- Osage County R-1
- Ozark High School
- Pattonville High School
- Pilot Grove C-4 School
- Reeds Spring High School
- Ritenour High School (MCAC)
- Rock Bridge Senior High
- Roosevelt High School
- Ruskin High School
- Salisbury R-IV High School
- Scott County Central
- Sherwood High School
- Soldan International Studies High School
- South Shelby High School
- STEAM Academy
- St. Vincent High School
- Sullivan High School
- Timberland High School
- Twin Rivers High School
- Union High School
- University City High School
- Walnut Grove R-V
- Warrensburg High School
- West Plains High School
- Westran High School
- William Chrisman High School